Do not take maprotiline if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan®), phenelzine (Nardil®), or tranylcypromine (Parnate®) within the last 14 days.

Tell your doctor if you have epilepsy or another seizure disorder, liver disease, kidney disease, are receiving electroshock therapy, have difficulty urinating or an enlarged prostate, glaucoma, high blood pressure, irregular heartbeats, heart disease, or had a heart attack in the last 6 weeks. You may not be able to take maprotiline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Furthermore, please inform your doctor if you are taking: a tricyclic antidepressant such as amitriptyline (Elavil®, Endep®), doxepin (Sinequan®), nortriptyline (Pamelor®), imipramine (Tofranil®), and others; another antidepressant such as citalopram (Celexa®), fluoxetine (Prozac®), fluvoxamine (Luvox®), paroxetine (Paxil®), or sertraline (Zoloft®); a barbiturate such as phenobarbital (Luminal®), butabarbital (Butisol®), amobarbital (Amytal®), or secobarbital (Seconal®); an anxiety or sleep medicine such as alprazolam (Xanax®), diazepam (Valium®), temazepam (Restoril®), and others; a phenothiazine such as prochlorperazine (Compazine®), chlorpromazine (Thorazine®), thioridazine (Mellaril®), mesoridazine (Serentil®), fluphenazine (Prolixin®, Permitil®), and others; a thyroid medicine such as levothyroxine (Synthroid®, Levoxyl®, Levothroid®, others); guanethidine (Ismelin®); cimetidine (Tagamet®, Tagamet HB®) or ranitidine (Zantac®, Zantac 75®); or propafenone (Rythmol®), quinidine (Cardioquin®, others), or amiodarone (Cordarone®). You may not be able to take maprotiline, or you may require a change in dosage or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with maprotiline. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Maprotiline is in the FDA pregnancy category B. This means that maprotiline is not likely to harm an unborn baby. Do not take maprotiline without first talking to your doctor if you are pregnant.

Additionally, maprotiline passes into breast milk and may affect a nursing infant. Do not take maprotiline without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects such as drowsiness, dizziness, unsteadiness, feeling uncoordinated, and low blood pressure. You may require a lower dose of this medication.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Maprotiline may cause drowsiness and dizziness. If you experience drowsiness or dizziness, try to avoid these activities.

Dizziness is likely to occur when you rise from a sitting or lying position. Stand up slowly to prevent dizziness and a possible fall.

Also, try to drink alcohol in moderation, or not at all. Alcohol may increase symptoms of drowsiness and dizziness while you are taking maprotiline.

 

FDA Information

Why is this medication prescribed?

Other uses for this medicine

Dosage and using this medicine

What should I do if I forget a dose?

What side effects can this medication cause?

What storage conditions are needed for this medicine?

In case of an emergency/overdose